Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antiparasite inhibitors | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(9E)-N-[(4-aminophenyl)sulfonyl]undec-9-enamide | - |
Plasmodium falciparum | |
(E)-2-(2,6-dimethylphenyl)ethenyl phenyl sulfone | - |
Plasmodium falciparum | |
(Z)-1-methyl-2-phenylethenyl phenyl sulfone | - |
Plasmodium falciparum | |
1,1'-disulfanediyldinaphthalen-2-ol | - |
Plasmodium falciparum | |
1-phenylethyl (2Z)-3-[(4,5-dimethyl-2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]but-2-enoate | - |
Plasmodium falciparum | |
2,2'-(benzene-1,3-diyldisulfonyl)dibenzene-1,4-diol | - |
Plasmodium falciparum | |
2,2'-disulfanediylbis(4-chlorophenol) | - |
Plasmodium falciparum | |
2,2'-disulfanediyldiphenol | - |
Plasmodium falciparum | |
2,2'-sulfanediylbis(4-chlorophenol) | - |
Plasmodium falciparum | |
2,2'-trisulfane-1,3-diylbis(4-chlorophenol) | - |
Plasmodium falciparum | |
2,5-dichloro-4-nitro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide | - |
Plasmodium falciparum | |
2,5-dichloro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide | - |
Plasmodium falciparum | |
2-(butylsulfonyl)ethyl 4-nitrobenzoate | - |
Plasmodium falciparum | |
2-(tert-butylsulfonyl)-1-(2,4-dichlorophenyl)ethanone | - |
Plasmodium falciparum | |
2-amino-6-(naphthalen-2-ylsulfonyl)quinazolin-4-ol | - |
Plasmodium falciparum | |
2-chloro-4-sulfanylphenol | - |
Plasmodium falciparum | |
2-hydroxy-4-[(phenylsulfonyl)amino]benzoic acid | - |
Plasmodium falciparum | |
2-[(4-aminocyclohexyl)sulfonyl]naphthalene-1,4-diol | - |
Plasmodium falciparum | |
2-[(4-aminophenyl)sulfonyl]benzene-1,4-diol | - |
Plasmodium falciparum | |
2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol | - |
Plasmodium falciparum | |
2-[(4-methylphenyl)sulfonyl]naphthalene-1,4-diol | - |
Plasmodium falciparum | |
2-[4-[3-bromo-4-(hydroxymethyl)phenyl]piperazin-1-yl]-1-(5-nitrofuran-2-yl)ethanone | - |
Plasmodium falciparum | |
3-[(4-aminophenyl)sulfonyl]-5-methylbenzene-1,2-diol | - |
Plasmodium falciparum | |
4,4'-disulfanediylbis(2,3,6-trichlorophenol) | - |
Plasmodium falciparum | |
4,4'-sulfanediyldibenzene-1,3-diol | - |
Plasmodium falciparum | |
4,4'-sulfonylbis(3-chloroaniline) | - |
Plasmodium falciparum | |
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide | - |
Plasmodium falciparum | |
4-chloro-2-[(4-hydroxyphenyl)sulfonyl]phenol | - |
Plasmodium falciparum | |
4-methylphenyl naphthalen-2-yl sulfone | - |
Plasmodium falciparum | |
4-methylphenyl phenyl sulfone | - |
Plasmodium falciparum | |
5-[[4-(hydroxyamino)phenyl]sulfonyl]-1,3-thiazol-2-amine | - |
Plasmodium falciparum | |
6-amino-2-hydroxy-2,5-dimethylhexanamide | - |
Plasmodium falciparum | |
benzyl (E)-2-[(4-methylphenyl)sulfanyl]ethenyl sulfone | - |
Plasmodium falciparum | |
bis(4-chlorophenyl)trisulfane | - |
Plasmodium falciparum | |
bis(4-methylphenyl)trisulfane | - |
Plasmodium falciparum | |
bis[4-(1-methylethyl)phenyl] sulfone | - |
Plasmodium falciparum | |
diphenyl sulfide | - |
Plasmodium falciparum | |
ethyl 4-methylpyridine-3-carboxylate | - |
Plasmodium falciparum | |
N-(3-chlorophenyl)benzenesulfonamide | - |
Plasmodium falciparum | |
N-(4-[[4-(acetylamino)phenyl]sulfonyl]phenyl)-2-hydroxybenzamide | - |
Plasmodium falciparum | |
N-[3,5-bis(trifluoromethyl)phenyl]-4-[[3,5-bis(trifluoromethyl)phenyl]amino]-3-nitrocyclopenta-1,3-diene-1-sulfonamide | - |
Plasmodium falciparum | |
S-[2-(4-methoxyphenyl)-2-oxoethyl] benzenesulfonothioate | - |
Plasmodium falciparum | |
thiolactomycin | - |
Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | Plasmodium falciparum | - |
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Plasmodium falciparum | 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-ACP synthase III | - |
Plasmodium falciparum |
beta-ketoacyl-acyl carrier protein synthase III | - |
Plasmodium falciparum |
KASIII | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00013 | - |
- |
Plasmodium falciparum | 1,1'-disulfanediyldinaphthalen-2-ol | |
0.00013 | - |
- |
Plasmodium falciparum | 4,4'-sulfonylbis(3-chloroaniline) | |
0.00014 | - |
- |
Plasmodium falciparum | 2,2'-disulfanediylbis(4-chlorophenol) | |
0.00024 | - |
- |
Plasmodium falciparum | 4,4'-disulfanediylbis(2,3,6-trichlorophenol) | |
0.00024 | - |
- |
Plasmodium falciparum | 6-amino-2-hydroxy-2,5-dimethylhexanamide | |
0.00028 | - |
- |
Plasmodium falciparum | 2,5-dichloro-4-nitro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide | |
0.00032 | - |
- |
Plasmodium falciparum | 2-(butylsulfonyl)ethyl 4-nitrobenzoate | |
0.00038 | - |
- |
Plasmodium falciparum | 2-[(4-methylphenyl)sulfonyl]naphthalene-1,4-diol | |
0.00044 | - |
- |
Plasmodium falciparum | 2-[(4-aminocyclohexyl)sulfonyl]naphthalene-1,4-diol | |
0.00052 | - |
- |
Plasmodium falciparum | benzyl (E)-2-[(4-methylphenyl)sulfanyl]ethenyl sulfone | |
0.00053 | - |
- |
Plasmodium falciparum | 2,2'-trisulfane-1,3-diylbis(4-chlorophenol) | |
0.00063 | - |
- |
Plasmodium falciparum | bis(4-chlorophenyl)trisulfane | |
0.00065 | - |
- |
Plasmodium falciparum | diphenyl sulfide | |
0.0014 | - |
- |
Plasmodium falciparum | bis(4-methylphenyl)trisulfane | |
0.0015 | - |
- |
Plasmodium falciparum | S-[2-(4-methoxyphenyl)-2-oxoethyl] benzenesulfonothioate | |
0.0019 | - |
- |
Plasmodium falciparum | 2,2'-disulfanediyldiphenol | |
0.0022 | - |
- |
Plasmodium falciparum | 2,5-dichloro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide | |
0.0028 | - |
- |
Plasmodium falciparum | 2-chloro-4-sulfanylphenol | |
0.0031 | - |
- |
Plasmodium falciparum | 2,2'-sulfanediylbis(4-chlorophenol) | |
0.0032 | - |
- |
Plasmodium falciparum | 2-[4-[3-bromo-4-(hydroxymethyl)phenyl]piperazin-1-yl]-1-(5-nitrofuran-2-yl)ethanone | |
0.0049 | - |
- |
Plasmodium falciparum | ethyl 4-methylpyridine-3-carboxylate | |
0.005 | - |
- |
Plasmodium falciparum | 2-hydroxy-4-[(phenylsulfonyl)amino]benzoic acid | |
0.0052 | - |
- |
Plasmodium falciparum | N-[3,5-bis(trifluoromethyl)phenyl]-4-[[3,5-bis(trifluoromethyl)phenyl]amino]-3-nitrocyclopenta-1,3-diene-1-sulfonamide | |
0.0108 | - |
- |
Plasmodium falciparum | 4,4'-sulfanediyldibenzene-1,3-diol | |
0.0183 | - |
- |
Plasmodium falciparum | 2-amino-6-(naphthalen-2-ylsulfonyl)quinazolin-4-ol | |
0.022 | - |
- |
Plasmodium falciparum | 5-[[4-(hydroxyamino)phenyl]sulfonyl]-1,3-thiazol-2-amine | |
0.0225 | - |
- |
Plasmodium falciparum | bis[4-(1-methylethyl)phenyl] sulfone | |
0.0258 | - |
- |
Plasmodium falciparum | 1-phenylethyl (2Z)-3-[(4,5-dimethyl-2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]but-2-enoate | |
0.0272 | - |
- |
Plasmodium falciparum | 3-[(4-aminophenyl)sulfonyl]-5-methylbenzene-1,2-diol | |
0.0382 | - |
- |
Plasmodium falciparum | 2,2'-(benzene-1,3-diyldisulfonyl)dibenzene-1,4-diol | |
0.0481 | - |
- |
Plasmodium falciparum | N-(4-[[4-(acetylamino)phenyl]sulfonyl]phenyl)-2-hydroxybenzamide | |
0.0537 | - |
- |
Plasmodium falciparum | 4-methylphenyl naphthalen-2-yl sulfone | |
0.0629 | - |
- |
Plasmodium falciparum | 2-(tert-butylsulfonyl)-1-(2,4-dichlorophenyl)ethanone | |
0.0638 | - |
- |
Plasmodium falciparum | 2-[(4-aminophenyl)sulfonyl]benzene-1,4-diol | |
0.075 | - |
- |
Plasmodium falciparum | thiolactomycin | |
0.1146 | - |
- |
Plasmodium falciparum | 4-chloro-2-[(4-hydroxyphenyl)sulfonyl]phenol | |
0.1575 | - |
- |
Plasmodium falciparum | 4-methylphenyl phenyl sulfone | |
0.1646 | - |
- |
Plasmodium falciparum | (Z)-1-methyl-2-phenylethenyl phenyl sulfone | |
0.1926 | - |
- |
Plasmodium falciparum | 2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol | |
0.1952 | - |
- |
Plasmodium falciparum | N-(3-chlorophenyl)benzenesulfonamide | |
0.4477 | - |
- |
Plasmodium falciparum | (E)-2-(2,6-dimethylphenyl)ethenyl phenyl sulfone | |
1 | - |
above | Plasmodium falciparum | 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide | |
1 | - |
above | Plasmodium falciparum | (9E)-N-[(4-aminophenyl)sulfonyl]undec-9-enamide |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in fatty acid synthesis initiation in Plasmodium falciparum, overview | Plasmodium falciparum |