Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor diffusion method, crystal structures of mtFabH and C112A mtFabH with 1 | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WNG3 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WNG3 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | data support a new model for catalysis, in which FabH exists in an open form that permits binding of the long chain acyl-coenzyme A substrate binding and release of the corresponding 3-ketoacyl ACP product. Catalysis and intermediate steps in the process are proposed to occur in a closed form of the mtFabH. These conformational changes may be critical for binding and dissociation steps in other enzymes of the FAS pathways, including transfers between the type I and type II FASII components of Mycobacterium tuberculosis | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
FabH | - |
Mycobacterium tuberculosis |