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Literature summary for 2.3.1.176 extracted from

  • Fu, Q.; Inankur, B.; Yin, J.; Striker, R.; Lan, Q.
    Sterol carrier protein 2, a critical host factor for dengue virus infection, alters the cholesterol distribution in mosquito Aag2 cells (2015), J. Med. Entomol., 52, 1124-1134.
    View publication on PubMed

Application

Application Comment Organism
medicine SCP2 is a critical host factor for dengue virus production in mosquito Aag2 cells. Treatment with inhibitor SCPI-1, or knockdown of SCP2 dramatically represses the virus production in mosquito but not mammalian cells.The intracellular cholesterol distribution in mosquito cells is altered by SCP2 inhibitor treatment, suggesting that SCP2-mediates cholesterol trafficking pathway that is important for dengue virus viral production. SCPI-1 treatment decreases cholesterol in both mammalian and mosquito cell lines, but this decrease in cholesterol only leads to a decline in viral titer in mosquito host cells Aedes aegypti

Inhibitors

Inhibitors Comment Organism Structure
SCPI-1 i.e. N-(4-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino]phenyl)acetamide hydrobromide Aedes aegypti

Organism

Organism UniProt Comment Textmining
Aedes aegypti Q86PR3
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