Application | Comment | Organism |
---|---|---|
medicine | SCP2 is a critical host factor for dengue virus production in mosquito Aag2 cells. Treatment with inhibitor SCPI-1, or knockdown of SCP2 dramatically represses the virus production in mosquito but not mammalian cells.The intracellular cholesterol distribution in mosquito cells is altered by SCP2 inhibitor treatment, suggesting that SCP2-mediates cholesterol trafficking pathway that is important for dengue virus viral production. SCPI-1 treatment decreases cholesterol in both mammalian and mosquito cell lines, but this decrease in cholesterol only leads to a decline in viral titer in mosquito host cells | Aedes aegypti |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SCPI-1 | i.e. N-(4-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino]phenyl)acetamide hydrobromide | Aedes aegypti |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aedes aegypti | Q86PR3 | - |
- |