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Literature summary for 2.3.1.17 extracted from

  • Ariyannur, P.S.; Moffett, J.R.; Manickam, P.; Pattabiraman, N.; Arun, P.; Nitta, A.; Nabeshima, T.; Madhavarao, C.N.; Namboodiri, A.M.
    Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS (2010), Brain Res., 1335, 1-13.
    View publication on PubMed
Search for more literature for 2.3.1.17

Activating Compound

Activating Compound Comment Organism Structure
Methamphetamine maximum increase in activity in SH-SY5Y cells is found at 1 microM methamphetamine at 24 h, increase in activity is about 2fold Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression HEK-293 cell Homo sapiens
expression HEK-293 cell Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modeling of the active site shows that only the amino acid aspartate, but not glutamate, can fit into the active site pocket Homo sapiens
molecular modeling of the active site shows that only the amino acid aspartate, but not glutamate, can fit into the active site pocket Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol enzyme is present in both cytoplasm and mitochondria Homo sapiens 5829
-
mitochondrion enzyme is present in both cytoplasm and mitochondria Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N9F0
-
-
Mus musculus Q3UGX3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-aspartate
-
 Homo sapiens CoA + N-acetyl-L-aspartic acid
-
 ?
acetyl-CoA + L-aspartate
-
 Mus musculus CoA + N-acetyl-L-aspartic acid
-
 ?
acetyl-CoA + L-glutamate less than 1% of the activity with L-aspartate Homo sapiens CoA + N-acetyl-L-glutamic acid
-
 ?
acetyl-CoA + L-glutamate less than 1% of the activity with L-aspartate Mus musculus CoA + N-acetyl-L-glutamic acid
-
 ?

Subunits

Subunits Comment Organism
? x * 33000-35000, SDS-PAGE of recombinant His-tagged protein Homo sapiens
? x * 33000-35000, SDS-PAGE of recombinant His-tagged protein Mus musculus

Synonyms

Synonyms Comment Organism
NAT8L
-
 Homo sapiens
NAT8L
-
 Mus musculus