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Literature summary for 2.3.1.17 extracted from

  • Goldstein, F.B.
    Biosynthesis of N-acetyl-L-aspartic acid (1959), J. Biol. Chem., 234, 2702-2706.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Acyl-AMP derivatives e.g. acetyl-AMP, butyryl-AMP, strong Rattus norvegicus
benzoyl-CoA weak Rattus norvegicus
fluoroacetyl-CoA weak Rattus norvegicus
propionyl-CoA weak Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km value for acetyl-CoA Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
KBr stimulates Rattus norvegicus
KCl 2fold enzyme activity at 0.05 - 0.1 M Rattus norvegicus
KClO3 stimulates Rattus norvegicus
KCNS stimulates Rattus norvegicus
KI stimulates Rattus norvegicus
KNO3 stimulates Rattus norvegicus
LiCl stimulates Rattus norvegicus
NaCl stimulates Rattus norvegicus
NaNO2 stimulates Rattus norvegicus
NH4Cl stimulates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-aspartate Rattus norvegicus
-
CoA + N-acetyl-L-aspartic acid
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
0-5°C, 8-10 mg protein/ml, stable for weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-aspartate
-
Rattus norvegicus CoA + N-acetyl-L-aspartic acid
-
?
acetyl-CoA + L-aspartate highly specific Rattus norvegicus CoA + N-acetyl-L-aspartic acid
-
?
additional information reduced CoA with acetyl-AMP can substitute for acetyl-CoA, about 50% of activity with acetyl-CoA Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
no enzyme activity after boiling Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.8
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.2 8 about 13% of maximal activity at pH 5.2, about 50% of maximal activity at pH 8.0 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki values for various inhibitors Rattus norvegicus