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Literature summary for 2.3.1.169 extracted from

  • Menon, S.; Ragsdale, S.W.
    Role of the [4Fe-4S] cluster in reductive activation of the cobalt center of the corrinoid iron-sulfur protein from Clostridium thermoaceticum during acetate biosynthesis (1998), Biochemistry, 37, 5689-5698.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
CO a cobalt-containing Co/Fe-S component of multienzyme complex serves as a methyl carrier in the pathway of methane synthesis from acetate Moorella thermoacetica
Fe corrinoid/iron-sulfur protein required Moorella thermoacetica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Moorella thermoacetica key enzyme in the autotrophic acetyl-CoA pathway, i.e. Wood pathway, enzyme catalyses the final steps in this pathway ?
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Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
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Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] the FeS cluster is present to relay electrons from enzyme to CO Moorella thermoacetica
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] the transfer of methyl group to enzyme occurs by SN2-type nucleophilic displacement, not a radical, reaction Moorella thermoacetica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CH3-(corrinoid/iron-sulfur protein) + CO + HS-CoA under anaerobic conditions Moorella thermoacetica CH3-CO-S-CoA + corrinoid/iron-sulfur protein
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CH3-tetrahydrofolate + CO + HS-CoA
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Moorella thermoacetica CH3-CO-S-CoA + tetrahydrofolate
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CO + methyl-X + HS-CoA
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Moorella thermoacetica CH3-CO-S-CoA + HX
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additional information key enzyme in the autotrophic acetyl-CoA pathway, i.e. Wood pathway, enzyme catalyses the final steps in this pathway Moorella thermoacetica ?
-
?