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Literature summary for 2.3.1.168 extracted from

  • Hu, C.W.; Griffin, T.A.; Lau, K.S.; Cox, R.P.; Chuang, D.T.
    Subunit structure of the dihydrolipoyl transacylase component of branched-chain alpha-keto acid dehydrogenase complex from bovine liver. Mapping of the lipoyl-bearing domain by limited proteolysis (1986), J. Biol. Chem., 261, 343-349.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52600
-
 x * 52600, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine Bos taurus
-
 CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Bos taurus CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine enzyme contains 1 lipoyl residue per E2 chain of branched-chain 2-oxo acid dehydrogenase Bos taurus CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?

Subunits

Subunits Comment Organism
? x * 52600, SDS-PAGE Bos taurus
More lipoate-free inner E2 core: 26 kDa fragment contains the active site, 22 kDa fragment B is the subunit-binding domain, fragments are gained by tryptic digest Bos taurus

Synonyms

Synonyms Comment Organism
More enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase Bos taurus