Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 10-deacetylbaccatin III | Taxus baccata | - |
CoA + baccatin III | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taxus baccata | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aerial part | - |
Taxus baccata | - |
additional information | higher content of 10-deacetylbaccatin III in the aerial part of the plantlets than in the roots | Taxus baccata | - |
root | - |
Taxus baccata | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 10-deacetylbaccatin III | - |
Taxus baccata | CoA + baccatin III | - |
? |
Synonyms | Comment | Organism |
---|---|---|
10-deacetylbaccatin III-10beta-O-acetyltransferase | - |
Taxus baccata |
DBAT | - |
Taxus baccata |
General Information | Comment | Organism |
---|---|---|
metabolism | the relationship between taxane patterns and the expression of genes encoding the enzymes taxadiene synthase, 10-deacetylbaccatin III-10beta-O-acetyltransferase, baccatin III 13-O-(3-amino-3-phenylpropanoyl) transferase and 3'-N-debenzoyl-2'-deoxytaxol-N-benzoyltransferase, involved in early and late steps of the taxane pathway, overview. The most abundant taxane in the aerial parts is 10-deacetylbaccatin III, which increases as the plantlets grow, indicating a low conversion to baccatin III and taxol. In contrast, the levels of 10-deacetylbaccatin III in the roots remain lower than those of taxol. But in the aerial parts the expression of DBAT, which codes for the enzyme that converts 10-deacetylbaccatin III into baccatin III, does not increase with the age of plantlets, unlike that of the other three enzymes, suggesting that this gene controls a rate-limiting step in the taxane biosynthetic pathway | Taxus baccata |