BRENDA - Enzyme Database show
show all sequences of 2.3.1.167

Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species

Hao, D.C.; Huang, B.; Yang, L.; Genetica 135, 123-135 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
into the TA cloning vector pMD19-T for sequencing
Taxus brevifolia
into the TA cloning vector pMD19-T for sequencing
Taxus canadensis
into the TA cloning vector pMD19-T for sequencing
Taxus cuspidata
into the TA cloning vector pMD19-T for sequencing
Taxus fuana
into the TA cloning vector pMD19-T for sequencing
Taxus globosa
into the TA cloning vector pMD19-T for sequencing
Taxus sumatrana
into the TA cloning vector pMD19-T for sequencing
Taxus wallichiana var. wallichiana
into the TA cloning vector pMD19-T for sequencing
Taxus x hunnewelliana
into the TA cloning vector pMD19-T for sequencing
Taxus x media
into the TA cloning vector pMD19-T for sequencing; into the TA cloning vector pMD19-T for sequencing
Taxus baccata
into the TA cloning vector pMD19-T for sequencing; into the TA cloning vector pMD19-T for sequencing
Taxus mairei
into the TA cloning vector pMD19-T for sequencing; into the TA cloning vector pMD19-T for sequencing
Taxus wallichiana var. chinensis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 10-deacetylbaccatin III
Taxus cuspidata
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus x media
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus wallichiana var. chinensis
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus x hunnewelliana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus mairei
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus fuana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus sumatrana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus globosa
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus canadensis
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus baccata
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus wallichiana var. wallichiana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus brevifolia
-
CoA + baccatin III
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Taxus baccata
B5KRG2
-
-
Taxus baccata
Q8W169
UniProt taxonomy T. baccata
-
Taxus brevifolia
B5KRG4
-
-
Taxus canadensis
B5KRF5
-
-
Taxus cuspidata
Q9M6E2
-
-
Taxus fuana
B5KRF8
UniProt taxonomy Taxus fuana
-
Taxus globosa
B5KRG6
-
-
Taxus mairei
B5KRG1
UniProt taxonomy T. wallichiana var. mairei
-
Taxus mairei
Q67DV6
UniProt taxonomy T. wallichiana var. mairei
-
Taxus sumatrana
B5KRG5
-
-
Taxus wallichiana var. chinensis
B5KRF6
; UniProt taxonomy T. wallichiana var. mairei
-
Taxus wallichiana var. chinensis
B5KRG3
-
-
Taxus wallichiana var. wallichiana
B5KRF7
-
-
Taxus x hunnewelliana
B5KRF3
-
-
Taxus x media
A0MPB1
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus cuspidata
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus x media
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus wallichiana var. chinensis
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus x hunnewelliana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus mairei
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus fuana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus sumatrana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus globosa
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus canadensis
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus baccata
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus wallichiana var. wallichiana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus brevifolia
CoA + baccatin III
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
into the TA cloning vector pMD19-T for sequencing
Taxus baccata
into the TA cloning vector pMD19-T for sequencing
Taxus brevifolia
into the TA cloning vector pMD19-T for sequencing
Taxus canadensis
into the TA cloning vector pMD19-T for sequencing
Taxus cuspidata
into the TA cloning vector pMD19-T for sequencing
Taxus fuana
into the TA cloning vector pMD19-T for sequencing
Taxus globosa
into the TA cloning vector pMD19-T for sequencing
Taxus mairei
into the TA cloning vector pMD19-T for sequencing
Taxus sumatrana
into the TA cloning vector pMD19-T for sequencing
Taxus wallichiana var. chinensis
into the TA cloning vector pMD19-T for sequencing
Taxus wallichiana var. wallichiana
into the TA cloning vector pMD19-T for sequencing
Taxus x hunnewelliana
into the TA cloning vector pMD19-T for sequencing
Taxus x media
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 10-deacetylbaccatin III
Taxus cuspidata
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus x media
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus wallichiana var. chinensis
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus x hunnewelliana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus mairei
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus fuana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus sumatrana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus globosa
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus canadensis
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus baccata
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus wallichiana var. wallichiana
-
CoA + baccatin III
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
Taxus brevifolia
-
CoA + baccatin III
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus cuspidata
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus x media
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus wallichiana var. chinensis
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus x hunnewelliana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus mairei
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus fuana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus sumatrana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus globosa
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus canadensis
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus baccata
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus wallichiana var. wallichiana
CoA + baccatin III
-
-
-
?
acetyl-CoA + 10-deacetylbaccatin III
-
686959
Taxus brevifolia
CoA + baccatin III
-
-
-
?
Other publictions for EC 2.3.1.167
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736700
Han
Bioproduction of baccatin III, ...
Taxus wallichiana var. chinensis, Taxus wallichiana var. chinensis var. mairei
J. Sci. Food Agric.
94
2376-2383
2014
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2
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720764
Onrubia
The relationship between TXS, ...
Taxus baccata
Plant Sci.
181
282-287
2011
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1
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1
1
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719235
Zhang
Effects of different elicitors ...
Taxus cuspidata, Taxus cuspidata T5
Cell Biol. Int.
18
e00009
2010
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4
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1
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1
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1
1
1
1
-
-
703336
Zhang
An endophytic taxol-producing ...
Cladosporium cladosporioides
Curr. Microbiol.
59
227-232
2009
-
-
-
-
-
-
-
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7
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703751
Zhang
An endophytic taxol-producing ...
Aspergillus candidus
FEMS Microbiol. Lett.
293
155-159
2009
-
-
-
-
-
-
-
-
-
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4
-
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685463
Hao
Phylogenetic relationships of ...
Taxus baccata, Taxus brevifolia, Taxus canadensis, Taxus floridana, Taxus fuana, Taxus globosa, Taxus mairei, Taxus sumatrana, Taxus wallichiana, Taxus wallichiana var. chinensis, Taxus wallichiana var. wallichiana
Biol. Pharm. Bull.
31
260-265
2008
-
-
11
-
-
-
-
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13
-
-
11
-
22
-
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-
11
-
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11
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11
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13
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11
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11
-
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11
-
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-
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-
-
-
-
686959
Hao
Molecular evolution of paclita ...
Taxus baccata, Taxus brevifolia, Taxus canadensis, Taxus cuspidata, Taxus fuana, Taxus globosa, Taxus mairei, Taxus sumatrana, Taxus wallichiana var. chinensis, Taxus wallichiana var. wallichiana, Taxus x hunnewelliana, Taxus x media
Genetica
135
123-135
2008
-
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12
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15
-
15
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15
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15
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15
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15
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704167
Ondari
The taxol pathway 10-O-acetylt ...
Taxus cuspidata
J. Am. Chem. Soc.
130
17187-17194
2008
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1
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1
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3
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1
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1
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3
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1
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3
3
706930
Katkovcinova
Expression of dbat and dbtnbt ...
Taxus baccata
Z. Naturforsch. C
63
721-730
2008
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1
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1
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1
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672726
Loncaric
Expression of an acetyl-CoA sy ...
Taxus sp.
Biotechnol. J.
2
266-274
2007
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2
1
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5
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1
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5
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688912
Guo
Molecular cloning and heterolo ...
Taxus x media
Mol. Biol. Rep.
34
89-95
2007
3
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1
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672704
DeJong
Genetic engineering of taxol b ...
Taxus brevifolia
Biotechnol. Bioeng.
93
212-224
2006
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1
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673024
Loncaric
Profiling a taxol pathway 10be ...
Taxus sp.
Chem. Biol.
13
309-317
2006
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1
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660432
Fang
Expression cloned cDNA for 10- ...
Taxus baccata
Protein Expr. Purif.
35
17-24
2004
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440288
Walker
Taxol biosynthetic genes ...
Taxus cuspidata
Phytochemistry
58
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Molecular cloning of a 10-deac ...
Taxus cuspidata
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583-587
2000
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Acetyl CoA: 10-deacetylbaccati ...
Taxus cuspidata
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1998
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