General Stability | Organism |
---|---|
very sensitive to proteolysis, significant stabilization by a combination of NADPH, acetyl-CoA, malonyl-CoA, PMSF, and dithitothreitol | Penicillium griseofulvum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NAD+ | 0.3 mM, 21% inhibition in crude extracts | Penicillium griseofulvum | |
NADH | 0.3 mM, 26% inhibition in crude extracts | Penicillium griseofulvum | |
NADP+ | 0.3 mM, 21% inhibition in crude extracts | Penicillium griseofulvum | |
nicotinamide hypoxanthine dinucleotide phosphate | reduced form, 0.3 mM, 32% inhibition in crude extracts, oxidized form, 0.3 mM, 24% inhibition in crude extracts | Penicillium griseofulvum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADPH | Penicillium griseofulvum | first enzyme of patulin biosynthetic pathway | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? | |
acetyl-CoA + malonyl-CoA + NADPH | Penicillium griseofulvum NRRL 2159A | first enzyme of patulin biosynthetic pathway | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium griseofulvum | - |
NRRL 2159A | - |
Penicillium griseofulvum | - |
also known as Penicillium urticae | - |
Penicillium griseofulvum NRRL 2159A | - |
NRRL 2159A | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADPH | - |
Penicillium griseofulvum | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? | |
acetyl-CoA + malonyl-CoA + NADPH | first enzyme of patulin biosynthetic pathway | Penicillium griseofulvum | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? | |
acetyl-CoA + malonyl-CoA + NADPH | - |
Penicillium griseofulvum NRRL 2159A | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? | |
acetyl-CoA + malonyl-CoA + NADPH | first enzyme of patulin biosynthetic pathway | Penicillium griseofulvum NRRL 2159A | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
half-life in crude extracts: 16 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1 mM PMSF: 53 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1.5 mM NADPH: 38 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1.5 mM NADP+: 36 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1.5 mM NADH: 27 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1.5 mM NAD+: 27 min | Penicillium griseofulvum |
30 | - |
half-life in crude extracts in the presence of 1.5 mM NADPH, 1 mM PMSF, 0.25 mM acetyl-CoA, 0.75 mM malonyl-CoA and 10 mM dithiothreitol: 188 min | Penicillium griseofulvum |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
more than 60% activity remains after 120 min at 30°C in the presence of PMSF, NADPH, acetyl-CoA and dithiothreitol | Penicillium griseofulvum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Penicillium griseofulvum |