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Literature summary for 2.3.1.161 extracted from

  • Kennedy, J.; Auclair, K.; Kendrew, S.G.; Park, C.; Vederas, J.C.; Hutchinson, C.R.
    Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis (1999), Science, 284, 1368-1372.
    View publication on PubMed

Application

Application Comment Organism
medicine antihypercholesterolemic activity Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ Aspergillus terreus reaction mechanism, interaction with LovC dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
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Organism

Organism UniProt Comment Textmining
Aspergillus terreus
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Reaction

Reaction Comment Organism Reaction ID
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O reaction mechanism Aspergillus terreus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ enzyme contains six active sites: ketosynthase, acyltransferase, dehydratase, enoyl reductase, ketoreductase and acyl carrier protein Aspergillus terreus dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
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acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ reaction mechanism, interaction with LovC Aspergillus terreus dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
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