Literature summary for 2.3.1.159 extracted from

Lukacin, R.; Schreiner, S.; Silber, K.; Matern, U.
Starter substrate specificities of wild-type and mutant polyketide synthases from Rutaceae (2005), Phytochemistry, 66, 277-284.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the starter substrates for chalcone synthase or acridone synthase reaction are placed in different topographies in the active site pocket of the enzymes. Therefore conformational changes in the periphery beyond the active site cavity volumes determine the product formation and interconversion of enzymes by mutation of the active sites is insufficient	Ruta graveolens

Organism

Organism	UniProt	Comment	Textmining
Ruta graveolens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 + H2O	the starter substrates for chalcone synthase or acridone synthase reaction are placed in different topographies in the active site pocket of the enzymes. Therefore conformational changes in the periphery beyond the active site cavity volumes determine the product formation and interconversion of enzymes by mutation of the active sites is insufficient	Ruta graveolens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-methylanthraniloyl-CoA + 3 malonyl-CoA	-	Ruta graveolens	1,3-dihydroxy-N-methylacridone + CoA + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ACS2	-	Ruta graveolens

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Release 2023.1 (January 2023)