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Literature summary for 2.3.1.157 extracted from

  • Zhou, Y.; Xin, Y.; Sha, S.; Ma, Y.
    Kinetic properties of Mycobacterium tuberculosis bifunctional GlmU (2011), Arch. Microbiol., 193, 751-757.
    View publication on PubMed

Application

Application Comment Organism
drug development GlmU is a target for drug development against Mycobacteria Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetics and kinetic analysis of the acetyltransferase activity of GlmU, overview Mycobacterium tuberculosis
0.061
-
alpha-D-glucosamine 1-phosphate pH 7.5, 37°C Mycobacterium tuberculosis
0.224
-
acetyl-CoA pH 7.5, 37°C Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ has no effect on the activity of GlmU acetyltransferase up to 50 mM Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis
-
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
?
additional information Mycobacterium tuberculosis GlmU also catalyzes the reaction of the N-acetylglucosamine-1-phosphate uridyltransferase, EC 2.7.7.23, catalyzing the synthesis of UDP-GlcNAc from GlcNAc-1-phosphate and UTP ?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
Mycobacterium tuberculosis CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
?
additional information GlmU also catalyzes the reaction of the N-acetylglucosamine-1-phosphate uridyltransferase, EC 2.7.7.23, catalyzing the synthesis of UDP-GlcNAc from GlcNAc-1-phosphate and UTP Mycobacterium tuberculosis ?
-
?

Synonyms

Synonyms Comment Organism
GlmU
-
Mycobacterium tuberculosis
glucosamine-1-phosphate acetyltransferase
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Mycobacterium tuberculosis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
16 80 activity range Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
82.47
-
acetyl-CoA pH 7.5, 25°C Mycobacterium tuberculosis
82.47
-
alpha-D-glucosamine 1-phosphate pH 7.5, 25°C Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
7 11 activity range Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function essentiality of GlmU to mycobacterial survival Mycobacterium tuberculosis