Application | Comment | Organism |
---|---|---|
synthesis | coexpression of Papaver somniferum enzymes salutaridine synthase, salutaridine reductase and salutaridinol in Saccharomyces cerevisiae allows for productive spontaneous rearrangement of salutaridinol-7-O-acetate and synthesis of thebaine from (R)-reticuline. A 7-gene pathway for the production of codeine and morphine from (R)-reticuline can be established. Yeast cell feeding assays using (R)-reticuline, salutaridine or codeine as substrates show that all enzymes are functionally coexpressed and that activity of salutaridine reductase and codeine-O-demethylase likely limit flux to morphine synthesis | Papaver somniferum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | Q94FT4 | - |
- |