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Literature summary for 2.3.1.15 extracted from
- Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis (2006), Proc. Natl. Acad. Sci. USA, 103, 19695-19700.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | GPAT3 may be useful as a target for the treatment of obesity | Mus musculus |
| medicine | GPAT3 may be useful as a target for the treatment of obesity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GPAT3 is localized to the endoplasmic reticulum when overexpressed in COS-7 cells | Mus musculus |
| GPAT3 is localized to the endoplasmic reticulum when overexpressed in COS-7 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + sn-glycerol 3-phosphate | Mus musculus | key enzyme in de novo triacylglycerol synthesis | CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? |  |
| acyl-CoA + sn-glycerol 3-phosphate | Homo sapiens | key enzyme in de novo triacylglycerol synthesis | CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | GPAT3 mRNA is dramatically upregulated during adipocyte differentiation | Mus musculus | - |
| adipocyte | GPAT3 mRNA is dramatically upregulated during adipocyte differentiation | Homo sapiens | - |
| adipose tissue | - |
Homo sapiens | - |
| brown adipose tissue | - |
Mus musculus | - |
| colon | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| small intestine | - |
Mus musculus | - |
| testis | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + sn-glycerol 3-phosphate | key enzyme in de novo triacylglycerol synthesis | Mus musculus | CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | key enzyme in de novo triacylglycerol synthesis | Homo sapiens | CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? | |
| lauroyl-CoA + sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-lauroyl-sn-glycerol 3-phosphate | - |
? | |
| lauroyl-CoA + sn-glycerol 3-phosphate | - |
Homo sapiens | CoA + 1-lauroyl-sn-glycerol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ER-associated GPAT | - |
Mus musculus |
| ER-associated GPAT | - |
Homo sapiens |
| GPAT3 | - |
Mus musculus |
| GPAT3 | - |
Homo sapiens |
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