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Literature summary for 2.3.1.147 extracted from

  • Astudillo, A.M.; Perez-Chacon, G.; Balgoma, D.; Gil-de-Gomez, L.; Ruiperez, V.; Guijas, C.; Balboa, M.A.; Balsinde, J.
    Influence of cellular arachidonic acid levels on phospholipid remodeling and CoA-independent transacylase activity in human monocytes and U937 cells (2011), Biochim. Biophys. Acta, 1811, 97-103.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
monocyte
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 Homo sapiens
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U-937 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
CoA-IT
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 Homo sapiens

General Information

General Information Comment Organism
physiological function CoA-independent transacylase is a major regulator of arachidonic acid metabolism in human monocytes. Arachidonic acid incorporation into phospholipids is similar in both monocytes and U-937 cells, but a marked difference in the rate of remodeling is appreciated. U-937 cells remodel arachidonic acid at a much faster rate than human monocytes. This difference is not related to the differentiation state of the U-937 cells, but rather to the low levels of esterified arachidonate found in U-937 cells compared to human monocytes. Incubating the U-937 cells in arachidonic acid-rich media increases the cellular content of this fatty acid and leads to a substantial decrease of the rate of phospholipid arachidonic acid remodeling, which is due to reduced CoA-independent transacylase activity Homo sapiens