Literature summary for 2.3.1.147 extracted from

Seeds, M.C.; Peachman, K.K.; Bowton, D.L.; Sivertson, K.L.; Chilton, F.H.
Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma (2009), Am. J. Respir. Cell Mol. Biol., 41, 358-366.

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Inhibitors

Inhibitors	Comment	Organism	Structure
SKF 98625	a reversible antagonist of CoA-IT, in vitro and in vivo inhibition, induces eosinophil apoptosis in vitro	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	individuals with and without asthma	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
eosinophil	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CoA-independent transacylase	-	Homo sapiens
CoA-IT	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.005	0.01	pH 7.4, 37°C, in cell-free assays	Homo sapiens	SKF 98625
0.015	0.025	pH 7.4, 37°C, in whole cell assays	Homo sapiens	SKF 98625

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in the high affinity-low capacity pathway. Cells use this pathway to rapidly incorporate and remodel arachinonic acid through various glycerophospholipids. The predominant enzymes in this pathway include long chain fatty-acid ligase, lysophospholipid: acyl-CoA acyltransferase, and acyl-CoA independent transacylase, overview	Homo sapiens
physiological function	arachidonic acid-phospholipid remodeling orchestrated by CoA-IT and gIVaPLA2 may function to regulate eosinophil apoptosis, overview. Regulation of arachidonic acid and phospholipid remodeling enzymes provides a mechanism for regulating not only eicosanoid production, but also the increased life-span of eosinophils in allergic asthma, overview	Homo sapiens

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Release 2023.1 (January 2023)