Cloned (Comment) | Organism |
---|---|
expression in HepG2 cell | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UKG9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
NB-69 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CrOT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression and knock-down of the enzyme gene in a model of hepatic cells. Increase in enzymic activity induces a decrease in medium chain fatty acid and very long chaichain fatty acid levels in the cell. These changes are accompanied by an increase in the level of mRNA encoding enzymes of the peroxisomal beta oxidation, while there is no change in mitochondrial function. A decrease in carnitine ocatanoyltransferase activity has the opposite effect. Results suggest that carnitine ocatanoyltransferase activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway | Homo sapiens |