Literature summary for 2.3.1.137 extracted from

Morillas, M.; Gomez-Puertas, P.; Roca, R.; Serra, D.; Asins, G.; Valencia, A.; Hegardt, F.G.
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT). Mutation of CPT 1 histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity (2001), J. Biol. Chem., 276, 45001-45008.

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Inhibitors

Inhibitors	Comment	Organism	Structure
malonyl-CoA	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.002	-	acyl-CoA	-	Rattus norvegicus
0.015	-	octanoyl-CoA	-	Rattus norvegicus
0.0167	-	acyl-CoA	mutant strain expressed in Saccharomyces cerevisiae COT A238D	Rattus norvegicus
0.172	-	L-carnitine	recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTwt	Rattus norvegicus
146	-	L-carnitine	recombinant enzyme expressed in Saccharomyces cerevisiae COT238D	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-
peroxisome	-	Rattus norvegicus	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acyl-CoA + L-carnitine	Rattus norvegicus	beta-oxidation of fatty acids	acyl-L-carnitine + CoA	-	r

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	rat	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-CoA + L-carnitine	-	Rattus norvegicus	acyl-L-carnitine + CoA	-	r
acyl-CoA + L-carnitine	beta-oxidation of fatty acids	Rattus norvegicus	acyl-L-carnitine + CoA	-	r

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Release 2023.1 (January 2023)