Any feedback?
Literature summary for 2.3.1.135 extracted from
- Impact of LCA-associated E14L LRAT mutation on protein stability and retinoid homeostasis (2017), Biochemistry, 56, 4489-4499 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in NIH-3T3 cell | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E14L | naturally occuring substitution localized in an N-terminal alpha-helix. The mutant protein is instable and shows accelerated proteosomal degradation. The instability of E14L does not abrogate the production of the visual chromophore in a cell-based assay. Eexpression of E14L leads to a rapid increase in cellular levels of retinoic acid upon retinoid supplementation | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95237 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LRAT | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
