Literature summary for 2.3.1.135 extracted from

Tang, X.H.; Su, D.; Albert, M.; Scognamiglio, T.; Gudas, L.J.
Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen (2009), Cancer Biol. Ther., 8, 1212-1213.

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Application

Application	Comment	Organism
medicine	study on the effects of ectopic expression of human lecithin:retinol acyltransferase on murine oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. In transgenic mice with targeted human LRAT expression to the basal layer of mouse skin and oral cavity epithelia, the retinyl ester levels in skin are 32% greater than those in wild-type mice, and topical treatment of the back skin with retinol results in greater increases in retinyl esters than in wild-type mouse skin. While 4-nitroquinoline 1-oxide treatment induces multifocal precancerous and cancer lesions in the tongues of both transgene positive and negative mice, higher percentages of transgene positive mice develop more severe tongue lesions of grades 3 and 4 than transgene negative mice after 4-nitroquinoline 1-oxide treatment. Carcinogen treatment also results in greater percentages of transgene positive mouse tongues with hyperplasia, dysplasia, and carcinoma than transgene negative mouse tongues. There are higher cyclooxygenase-2 and lower RARbeta(2) mRNA levels in transgene positive mouse tongues as compared to wild-type mouse tongues after 4-nitroquinoline 1-oxide treatment	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	ectopic expression of human lecithin:retinol acyltransferase in murine basal layer of mouse skin and oral cavity epithelia	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)