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Literature summary for 2.3.1.135 extracted from

  • Golczak, M.; Imanishi, Y.; Kuksa, V.; Maeda, T.; Kubota, R.; Palczewski, K.
    Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle (2005), J. Biol. Chem., 280, 42263-42273.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
inducible expression of LRAT in HEK-293S cells Mus musculus
inducible expression of LRAT in HEK-293S cells Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
retinylamine
-
Bos taurus
retinylamine
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitamin A, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis ?
-
?
additional information Mus musculus LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitaminA, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis ?
-
?
phosphatidylcholine + all-trans-retinol Bos taurus LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A 2-acylglycerophosphocholine + all-trans-retinyl ester
-
?
phosphatidylcholine + all-trans-retinol Mus musculus LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A 2-acylglycerophosphocholine + retinyl ester
-
?
phosphatidylcholine + all-trans-retinylamine Bos taurus
-
2-acylglycerophosphocholine + all-trans-retinyl acylamide
-
?
phosphatidylcholine + retinylamine Mus musculus
-
2-acylglycerophosphocholine + fatty acid N-retinylamide
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
Mus musculus
-
eye
-
Bos taurus
-
liver
-
Mus musculus
-
retinal pigment epithelium
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitamin A, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis Bos taurus ?
-
?
additional information LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitaminA, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis Mus musculus ?
-
?
phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl ester
-
?
phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group, chain length C14-C18, from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl ester product identification ?
phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Mus musculus 2-acylglycerophosphocholine + retinyl ester
-
?
phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group, chain length C14-C18, from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Mus musculus 2-acylglycerophosphocholine + retinyl ester product identification ?
phosphatidylcholine + all-trans-retinylamine
-
Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl acylamide
-
?
phosphatidylcholine + all-trans-retinylamine
-
Bos taurus 2-acylglycerophosphocholine + fatty acid-N-all-trans-retinyl amide product identification ?
phosphatidylcholine + retinylamine
-
Mus musculus 2-acylglycerophosphocholine + fatty acid N-retinylamide
-
?
phosphatidylcholine + retinylamine
-
Mus musculus 2-acylglycerophosphocholine + fatty acid N-retinylamide product identification ?

Synonyms

Synonyms Comment Organism
lecithin:retinol acyltransferase
-
Mus musculus
lecithin:retinol acyltransferase
-
Bos taurus
LRAT
-
Mus musculus
LRAT
-
Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus
7.5
-
assay at Bos taurus