Application | Comment | Organism |
---|---|---|
diagnostics | the Lrat knockout mutant mice may serve as animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene Lrat, vector cloning for construction of knockout mutants | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene Lrat disruption by targeted recombination for generation of a homozygous knockout mutant, the mutant mice develop normally, but the rod outer segments in the retina are about 35% shorter than those of wild-type mice, rod and cone visual functions are severely attenuated at an early age | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | Mus musculus | lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Lrat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | retinal, pigmented | Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | determination of retinoid levels in liver, blood, and lung of wild-type and knockout mutant mice | Mus musculus | - |
retina | pigmented epithelial cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | - |
Mus musculus | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver | Mus musculus | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lecithin-retinol acyltransferase | - |
Mus musculus |
LRAT | - |
Mus musculus |