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Literature summary for 2.3.1.135 extracted from
- Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney (2003), Clin. Cancer Res., 9, 4897-4905.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | enzyme might be a prognostic or therapeutic marker in renal cancer | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | Homo sapiens | renal cell carcinomata contain greatly reduced levels of retinol and retinyl esters relative to healthy kidney tissue | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Bowman's capsule | in the glomeruli of normal, neoplastic kidney sections | Homo sapiens | - |
| epithelium | of renal tubules | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| kidney tumor cell | - |
Homo sapiens | - |
| additional information | renal tissue expression pattern, expression is higher in renal tumor than in normal tissue | Homo sapiens | - |
| renal cell carcinoma cell | metastatic | Homo sapiens | - |
| renal glomerulus | - |
Homo sapiens | - |
| renal tubule | epithelial cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | - |
Homo sapiens | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | renal cell carcinomata contain greatly reduced levels of retinol and retinyl esters relative to healthy kidney tissue | Homo sapiens | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lecithin:retinol acyltransferase | - |
Homo sapiens |
| LRAT | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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