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Literature summary for 2.3.1.135 extracted from
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces lecithin: retinol acyltransferase transcription in the rat kidney (2003), Chem. Biol. Interact., 145, 1-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the pollutant 2,3,7,8-tetrachlorodibenzo-4-dioxin, i.e. TCDD, induces enzyme expression in the kidney, induction mechanism, the expression of the cellular retinol binding protein I is unaffected, TCDD alters the retinoid metabolism regulation, expression and activity of cytochrome P450 A1 increases retinoic acid levels in kidney and liver, and enhances enzyme expression in the kidney | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | retinoids play an essential role in development and throughout life, levels in rat tissue after treatment with 2,3,7,8-tetrachlorodibenzo-4-dioxin, overview | ? | - |
? |  |
| phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | Rattus norvegicus | enzyme and cellular retinol binding protein I, CRBP I are involved in retinoid storage regulation, retinoid biosynthetic pathway, overview | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | the retinyl ester is the storage form of retinoids, retinol is the precursor for retinal, which has a function as visual chromophore, and subsequently of retinoic acid, which is a signaling hormone | r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | retinoids play an essential role in development and throughout life, levels in rat tissue after treatment with 2,3,7,8-tetrachlorodibenzo-4-dioxin, overview | Rattus norvegicus | ? | - |
? | |
| phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | - |
Rattus norvegicus | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | - |
r | |
| phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] | enzyme and cellular retinol binding protein I, CRBP I are involved in retinoid storage regulation, retinoid biosynthetic pathway, overview | Rattus norvegicus | 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] | the retinyl ester is the storage form of retinoids, retinol is the precursor for retinal, which has a function as visual chromophore, and subsequently of retinoic acid, which is a signaling hormone | r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lecithin: retinol acyltransferase | - |
Rattus norvegicus |
| LRAT | - |
Rattus norvegicus |
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