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Literature summary for 2.3.1.135 extracted from
- Membrane-bound lecithin-retinol acyltransferase (2002), Biochem. Biophys. Res. Commun., 292, 1243-1250.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not readily inhibitable by serine-directed chemical reagents; readily inactivated by organomercurials in the micromolar range | Bos taurus | |
| additional information | - |
Homo sapiens | |
| additional information | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + all-trans-retinol | Homo sapiens | - |
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? |  |
| phosphatidylcholine + all-trans-retinol | Bos taurus | - |
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + all-trans-retinol | Rattus norvegicus | important role in absorption and storage of vitamin A | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity labeling with all-trans-retinyl-alpha-bromoacetate, SDS electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification | Bos taurus |
| affinity labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, precipitation and gel electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification | Bos taurus |
| labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, affinity chromatography, avidin, prior to affinity chromatography or affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dipalmitoylphosphatidylcholine + all-trans-retinol | - |
Homo sapiens | all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine | - |
? | |
| dipalmitoylphosphatidylcholine + all-trans-retinol | - |
Rattus norvegicus | all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine | - |
? | |
| dipalmitoylphosphatidylcholine + all-trans-retinol | - |
Bos taurus | all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine | - |
? | |
| additional information | all-trans-retinol is a far better substrate than 11-cis-retinol | Bos taurus | ? | - |
? | |
| additional information | only fatty acyl group at the sn-1 is transferred | Homo sapiens | ? | - |
? | |
| additional information | only fatty acyl group at the sn-1 is transferred | Rattus norvegicus | ? | - |
? | |
| additional information | the fatty acid in the 2-position is important in substrate recognition | Homo sapiens | ? | - |
? | |
| additional information | the fatty acid in the 2-position is important in substrate recognition | Rattus norvegicus | ? | - |
? | |
| additional information | the fatty acid in the 2-position is important in substrate recognition | Bos taurus | ? | - |
? | |
| phosphatidylcholine + all-trans-retinol | - |
Homo sapiens | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + all-trans-retinol | - |
Bos taurus | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + all-trans-retinol | important role in absorption and storage of vitamin A | Rattus norvegicus | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + retinol-(cellular-retinol-binding-protein) | - |
Homo sapiens | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) | - |
? | |
| phosphatidylcholine + retinol-(cellular-retinol-binding-protein) | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) | - |
? | |
| phosphatidylcholine + retinol-(cellular-retinol-binding-protein) | - |
Bos taurus | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) | - |
? | |
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Release 2023.1 (January 2023)
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