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Literature summary for 2.3.1.135 extracted from

  • Zolfaghari, R.; Ross, A.C.
    Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid (2000), J. Lipid Res., 41, 2024-2034.
    View publication on PubMed
Search for more literature for 2.3.1.135

Activating Compound

Activating Compound Comment Organism Structure
retinoic acid
-
 Mus musculus
retinoic acid
-
 Rattus norvegicus
Vitamin A regulates LRAT activity in the liver but not in the small intestine Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cells Mus musculus
expression in HEK-293T cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + all-trans-retinol Mus musculus
-
 all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
phosphatidylcholine + all-trans-retinol Rattus norvegicus
-
 all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JI60 Balb-C line, vitamin A sufficient and deficient diet fed
-
Rattus norvegicus Q9JI61 vitamin A deficient and sufficient diet fed
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland mRNA expression Rattus norvegicus
-
intestine
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver undetectable in vitamin A depleted rats Rattus norvegicus
-
lung mRNA expression Rattus norvegicus
-
skeletal muscle mRNA expression Rattus norvegicus
-
small intestine
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + all-trans-retinol
-
 Mus musculus all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
phosphatidylcholine + all-trans-retinol
-
 Rattus norvegicus all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
 Mus musculus 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
 ?
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
 Rattus norvegicus 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Rattus norvegicus
monomer 1 × 25800, fully active catalytically Mus musculus