Cloned (Comment) | Organism |
---|---|
inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase is expressed as a GST fusion protein | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | association of the pyruvate dehydrogenase kinase2 and GST-L2 (glutathione-S-transferase fused to the inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase (E2)) dimers is enhanced by K+ | Homo sapiens | |
phosphate | phosphate has a pronounced effect in increasing ligand interference with pyruvate dehydrogenase kinase2 and GST-L2 (glutathione-S-transferase fused to the inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase (E2)) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
dimer | GST-L2, glutathione-S-transferase fused to the inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase exists as a dimer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoyl acetyltransferase | glutathione-S-transferase fused to the inner lipoyl domain is used | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Nov3r a lipoyl group-binding site inhibitor (related trifluoro-2-hydroxy-2-menthylpropionate compound) prevents pyruvate dehydrogenase kinase2 and GST-L2 (glutathione-S-transferase fused to the inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase) binding and dissect the effects of Nov3r binding at the lipoyl group binding site on PDHK2 binding of other ligands | Homo sapiens |