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Literature summary for 2.3.1.12 extracted from

  • Easlon, E.; Tsang, F.; Dilova, I.; Wang, C.; Lu, S.P.; Skinner, C.; Lin, S.J.
    The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension (2007), J. Biol. Chem., 282, 6161-6171.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.12

Application

Application Comment Organism
molecular biology dihydrolipoamide acetyltransferase is shown to be a metabolic longevity factor and is required for calorie restriction-mediated life span extension Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information deleting the LAT1 gene abolishes life span extension induced by calorie restriction. Overexpressing Lat1 extends life span, and this life span extension is not further increased by calorie restriction. Similar to calorie restriction, life span extension by Lat1 overexpression largely requires mitochondrial respiration. Lat1 overexpression does not require the Sir2 family to extend life span, suggesting that Lat1 mediates a branch of the calorie restriction pathway that functions in parallel to the Sir2 family Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae Lat1 is a limiting longevity factor in nondividing cells. Overexpressing Lat1 extends cell survival during prolonged culture at stationary phase. Studies suggest that Lat1 overexpression extends life span by increasing metabolic fitness of the cell ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Saccharomyces cerevisiae A6ZS09
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Lat1 is a limiting longevity factor in nondividing cells. Overexpressing Lat1 extends cell survival during prolonged culture at stationary phase. Studies suggest that Lat1 overexpression extends life span by increasing metabolic fitness of the cell Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
dihydrolipoamide acetyltransferase E2 component of the mitochondrial pyruvate dehydrogenase complex Saccharomyces cerevisiae
dihydrolipoyl transacetylase
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 Saccharomyces cerevisiae
Lat1
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 Saccharomyces cerevisiae
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component
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 Saccharomyces cerevisiae