Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
E199A | completely inactive mutant | Mycobacterium tuberculosis |
G222P | completely inactive mutant | Mycobacterium tuberculosis |
additional information | binary complex of Mtb-DapD and succinyl-CoA | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetate | caused by inhibition of succinyl-CoA-binding or pH effect | Mycobacterium tuberculosis | |
Co2+ | partial inhibition | Mycobacterium tuberculosis | |
Zn2+ | 1 mM, complete loss of enzyme acitivity | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | slight increase of enzyme activity | Mycobacterium tuberculosis | |
Mg2+ | stabilizes quartenary enzyme structure, slight increase of enzyme activity | Mycobacterium tuberculosis | |
Mn2+ | slight increase of enzyme activity | Mycobacterium tuberculosis | |
Na+ | stabilizes quartenary enzyme structure | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WP21 | - |
- |
Purification (Comment) | Organism |
---|---|
affinity and size-exclusion chromatography | Mycobacterium tuberculosis |
Subunits | Comment | Organism |
---|---|---|
trimer | - |
Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
DapD | - |
Mycobacterium tuberculosis |
Mtb-DapD | in complex with cofactor succinyl-CoA | Mycobacterium tuberculosis |
tetrahydrodipicolinate N-succinyltransferase | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | part of L-lysine biosynthetic pathway | Mycobacterium tuberculosis |