Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | analysis of KATi, bisubstrate analogues, natural compounds and synthetic derivatives, mechanism of action, structure-activity relationships, and pharmacokinetic/pharmacodynamic properties, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine40 | Homo sapiens | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine40 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5SQI0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine40 | - |
Homo sapiens | CoA + [alpha-tubulin]-N6-acetyl-L-lysine40 | - |
? | |
additional information | the enzyme shows tubulin-specific acetylation activity | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
alpha-tubulin N-acetyltransferase 1 | UniProt | Homo sapiens |
alphaTAT1 | - |
Homo sapiens |
ATAT1 | - |
Homo sapiens |
KAT | - |
Homo sapiens |
lysine acetyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the dysregulation of this enzyme activity is implicated in many human pathologies such as cancer, neurological and inflammatory disorders | Homo sapiens |
additional information | despite having a tertiary structure similar to that of Gcn5, alphaTAT1 contains a relatively wide substrate binding pocket and unique structural elements that play an essential role in alpha-tubulin-specific acetylation, which is associated with many cellular processes connected to cancer dissemination such as cell adhesion, migration and invasion, tertiary enzyme structure in complex with acetyl-CoA (PDB ID 4gs4) | Homo sapiens |
physiological function | lysine acetylation is a post-translational modification of both histone and nonhistone proteins that is catalyzed by lysine acetyltransferases and plays a key role in numerous biological contexts. Enzyme alphaTAT1 is involved in cell adhesion, migration, and invasion. It is the main KAT responsible for alpha-tubulin acetylation at Lys40 in higher organisms | Homo sapiens |