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Literature summary for 2.3.1.108 extracted from

  • Yang, W.; Guo, X.; Thein, S.; Xu, F.; Sugii, S.; Baas, P.; Radda, G.; Han, W.
    Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of alpha-tubulin (2013), Biochem. J., 449, 605-612.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K341
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Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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Mus musculus
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adipocyte acetylation of alpha-tubulin is up-regulated during adipogenesis, and adipocyte development is dependent on alpha-tubulin acetylation Mus musculus
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General Information

General Information Comment Organism
physiological function acetylation of alpha-tubulin is up-regulated during adipogenesis, and adipocyte development is dependent on alpha-tubulin acetylation. Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 and HDAC6. Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells. Katanin, a microtubule-severing protein with enhanced activity on acetylated alpha-tubulin, is actively involved in adipogenesis Mus musculus