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Literature summary for 2.3.1.108 extracted from
- Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans (2010), Proc. Natl. Acad. Sci. USA, 107, 21238-21239.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genes alphaTAT/MEC-17, phylogenetic analysis | Homo sapiens |
| genes alphaTAT/MEC-17, phylogenetic analysis | Caenorhabditis elegans |
| genes alphaTAT/MEC-17, phylogenetic analysis | Tetrahymena sp. |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + [alpha-tubulin]-L-lysine | Homo sapiens | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? |  |
| acetyl-CoA + [alpha-tubulin]-L-lysine | Caenorhabditis elegans | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
| acetyl-CoA + [alpha-tubulin]-L-lysine | Tetrahymena sp. | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
| additional information | Homo sapiens | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? | |
| additional information | Caenorhabditis elegans | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? | |
| additional information | Tetrahymena sp. | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Tetrahymena sp. | - |
gene MEC17 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | most Caenorhabditis elegans-ciliated sensory neurons lack detectable acetylated tubulin | Caenorhabditis elegans | - |
| neuron | MEC-12 is present in touch receptor neurons and other (ciliated) neurons. mec-17 expression is limited to touch receptor neurons, its paralogue atat-2 is also expressed in some ciliated neurons | Caenorhabditis elegans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Homo sapiens | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
| acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Caenorhabditis elegans | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
| acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Tetrahymena sp. | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
| additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Homo sapiens | ? | - |
? | |
| additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Caenorhabditis elegans | ? | - |
? | |
| additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Tetrahymena sp. | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alphaTAT | - |
Homo sapiens |
| alphaTAT | - |
Caenorhabditis elegans |
| alphaTAT | - |
Tetrahymena sp. |
| Mec-17 | - |
Homo sapiens |
| Mec-17 | - |
Caenorhabditis elegans |
| Mec-17 | - |
Tetrahymena sp. |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Homo sapiens | |
| acetyl-CoA | - |
Caenorhabditis elegans | |
| acetyl-CoA | - |
Tetrahymena sp. | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Homo sapiens |
| evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Caenorhabditis elegans |
| evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Tetrahymena sp. |
| malfunction | a delay in cilium formation for cultured human cells depleted of alphaTAT/MEC-17 | Homo sapiens |
| malfunction | disrupting MEC17 in Tetrahymena abolishes tubulin acetylation, but no overt defect in cilium formation or motility occurs | Tetrahymena sp. |
| malfunction | loss of Caenorhabditis elegans alphaTAT activity in the mec-17, atat-2 double mutant affects touch receptor neuron mechanosensation to a greater extent than having a nonacetylatable MEC-12 (K40R) form of tubulin in the organism | Caenorhabditis elegans |
| physiological function | MEC-17 and ATAT-2 are required for body touch sensation, which depends on the nonciliated, acetylated tubulin-containing touch receptor neurons. ATAT-2 is needed for acetylating tubulin in dendritic processes and cilia in those neurons. Additional role(s) for the acetyltransferase independent of tubulin acetylation | Caenorhabditis elegans |
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Release 2023.1 (January 2023)
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