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show all sequences of 2.3.1.105

A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen

Lee, T.C.; Malone, B.; Snyder, F.; J. Biol. Chem. 261, 5373-5377 (1986)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Sodium vanadate
inhibits at concentrations above 0.025 mM
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.226
-
acetyl-CoA
apparent Km at pH 8.4 and 23°C
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Na+
50 nM NaF increases the synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphate
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
Rattus norvegicus
involved in biosynthesis of thrombocyte activating factor in animal tissue
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
Rattus norvegicus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
renal cortex
-
Rattus norvegicus
-
renal medulla
-
Rattus norvegicus
-
spleen
highest activity
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
involved in biosynthesis of thrombocyte activating factor in animal tissue
486103
Rattus norvegicus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.4
-
-
Rattus norvegicus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
8
8.8
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Sodium vanadate
inhibits at concentrations above 0.025 mM
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.226
-
acetyl-CoA
apparent Km at pH 8.4 and 23°C
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Na+
50 nM NaF increases the synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphate
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
Rattus norvegicus
involved in biosynthesis of thrombocyte activating factor in animal tissue
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
Rattus norvegicus
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
renal cortex
-
Rattus norvegicus
-
renal medulla
-
Rattus norvegicus
-
spleen
highest activity
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
involved in biosynthesis of thrombocyte activating factor in animal tissue
486103
Rattus norvegicus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486103
Rattus norvegicus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.4
-
-
Rattus norvegicus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
8
8.8
-
Rattus norvegicus
Other publictions for EC 2.3.1.105
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
660411
Nomikos
Application of a TCA-precipita ...
Homo sapiens
Prostaglandins
73
123-140
2004
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486104
Baker
MgATP inhibits the synthesis o ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1213
27-33
1994
3
-
-
-
-
-
10
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
10
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486105
Baker
The potential for platelet-act ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1170
157-164
1993
1
-
-
-
-
-
2
2
2
1
-
1
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
2
2
1
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
486103
Lee
A new de novo pathway for the ...
Rattus norvegicus
J. Biol. Chem.
261
5373-5377
1986
-
-
-
-
-
-
1
1
1
1
-
1
-
2
-
-
-
-
-
7
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
1
-
1
-
-
-
-
-
7
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-