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Literature summary for 2.3.1.1 extracted from

  • Haas, D.; Leisinger, T.
    Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines (1974), Biochem. Biophys. Res. Commun., 60, 42-47.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,3-diaminopropane 10 mM, 88% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
arginine 0.2 mM, 73% inhibition, 97% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
cadaverine 10 mM, 80% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
polyamines
-
 Pseudomonas aeruginosa
putrescine 10 mM, 74% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
spermidine 1 mM, 78% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
spermine 1 mM, 88% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-glutamate Pseudomonas aeruginosa enzyme catalyzes the first step in the biosynthesis of arginine CoA + N-acetyl-L-glutamate
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, hydroxyapatite, 10fold purification Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
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 Pseudomonas aeruginosa CoA + N-acetyl-L-glutamate
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 ?
acetyl-CoA + L-glutamate enzyme catalyzes the first step in the biosynthesis of arginine Pseudomonas aeruginosa CoA + N-acetyl-L-glutamate
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 ?