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Literature summary for 2.2.1.7 extracted from

  • Kim, S.; Kuzuyama, T.; Chang, Y.; Song, K.; Kim, S.
    Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis (2006), Planta Med., 72, 234-240.
    View publication on PubMed
Search for more literature for 2.2.1.7

Cloned(Commentary)

Cloned (Comment) Organism
gene dxs2, cloning from embryonic roots, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in and complementation of an enzyme-deficient Escherichia coli mutant strain Ginkgo biloba

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ginkgo biloba gingkolides are diterpenoids and potent platelet-activating factor antagonists ?
-
 ?
pyruvate + D-glyceraldehyde 3-phosphate Ginkgo biloba the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, overview, gingkolides are synthesized in roots and then translocated to the leaves 1-deoxy-D-xylulose 5-phosphate + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Ginkgo biloba Q5J7B4 gene dxs1 and dxs2
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Source Tissue

Source Tissue Comment Organism Textmining
embryo culture Ginkgo biloba
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leaf DXS1 Ginkgo biloba
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additional information DXS2 is exclusively expressed in embryonic roots, while DXS1 is expressed to a higher extent in leaves Ginkgo biloba
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root
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 Ginkgo biloba
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information gingkolides are diterpenoids and potent platelet-activating factor antagonists Ginkgo biloba ?
-
 ?
pyruvate + D-glyceraldehyde 3-phosphate
-
 Ginkgo biloba 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?
pyruvate + D-glyceraldehyde 3-phosphate the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, overview, gingkolides are synthesized in roots and then translocated to the leaves Ginkgo biloba 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
DXS
-
 Ginkgo biloba