Literature summary for 2.2.1.7 extracted from

Altincicek, B.; Hintz, M.; Sanderbrand, S.; Wiesner, J.; Beck, E.; Jomaa, H.
Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa (2000), FEMS Microbiol. Lett., 190, 329-333.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
Fluoropyruvate	recombinant protein, 50% inhibition at 0.4 mM, fluoropyruvate is supposed to bind covalently to the active site	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
histidine-tagged recombinant protein, expressed in Escherichia coli	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + D-glyceraldehyde 3-phosphate	-	Pseudomonas aeruginosa	1-deoxy-D-xylulose 5-phosphate + CO2	-	?
pyruvate + DL-glyceraldehyde 3-phosphate	-	Pseudomonas aeruginosa	1-deoxy-D-xylulose 5-phosphate + CO2	-	?

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Release 2023.1 (January 2023)