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Literature summary for 2.2.1.6 extracted from
- The 138th residue of acetohydroxyacid synthase in Corynebacterium glutamicum is important for the substrate binding specificity (2019), Enzyme Microb. Technol., 129, 109357 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Corynebacterium glutamicum wild type strain ATCC14067 and its mutant YTW-104 | Corynebacterium glutamicum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the 138th (alanine) and 404th (valine) residues in the subunit IlvB play important roles in the substrate preference of the condensation reaction catalyzed by the enzyme | Corynebacterium glutamicum |
| additional information | the 138th (valine) and 404th (alanine) residues in the subunit IlvB play important roles in the substrate preference of the condensation reaction catalyzed by the enzyme. The 138th valine of subunit IlvB is beneficial for the L-valine biosynthesis | Corynebacterium glutamicum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 pyruvate | Corynebacterium glutamicum | - |
2-acetolactate + CO2 | - |
? |  |
| 2 pyruvate | Corynebacterium glutamicum VWB-1 | - |
2-acetolactate + CO2 | - |
? | |
| 2 pyruvate | Corynebacterium glutamicum IWJ001 | - |
2-acetolactate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | Corynebacterium glutamicum | - |
acetohydroxybutyrate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | Corynebacterium glutamicum VWB-1 | - |
acetohydroxybutyrate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | Corynebacterium glutamicum IWJ001 | - |
acetohydroxybutyrate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium glutamicum | - |
- |
- |
| Corynebacterium glutamicum IWJ001 | - |
- |
- |
| Corynebacterium glutamicum VWB-1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 pyruvate | - |
Corynebacterium glutamicum | 2-acetolactate + CO2 | - |
? | |
| 2 pyruvate | - |
Corynebacterium glutamicum VWB-1 | 2-acetolactate + CO2 | - |
? | |
| 2 pyruvate | - |
Corynebacterium glutamicum IWJ001 | 2-acetolactate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | - |
Corynebacterium glutamicum | acetohydroxybutyrate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | - |
Corynebacterium glutamicum VWB-1 | acetohydroxybutyrate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | - |
Corynebacterium glutamicum IWJ001 | acetohydroxybutyrate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetohydroxyacid synthase | - |
Corynebacterium glutamicum |
| AHAS | - |
Corynebacterium glutamicum |
| ilvB | catalytic subunit | Corynebacterium glutamicum |
| IlvN | regulatory subunit | Corynebacterium glutamicum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | - |
Corynebacterium glutamicum | |
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Release 2023.1 (January 2023)
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