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Literature summary for 2.2.1.6 extracted from

  • Zuljan, F.A.; Repizo, G.D.; Alarcon, S.H.; Magni, C.
    alpha-Acetolactate synthase of Lactococcus lactis contributes to pH homeostasis in acid stress conditions (2014), Int. J. Food Microbiol., 188, 99-107.
    View publication on PubMed
Search for more literature for 2.2.1.6

Cloned(Commentary)

Cloned (Comment) Organism
gene als, amino acid sequence determination and analysis, sequence comparisons Lactococcus lactis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 pyruvate Lactococcus lactis
-
 2-acetolactate + CO2
-
 ?
2 pyruvate Lactococcus lactis IL1403
-
 2-acetolactate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-
Lactococcus lactis Q7DAV2 gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als
-
Lactococcus lactis IL1403
-
-
-
Lactococcus lactis IL1403 Q7DAV2 gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information growth conditions and pH-dependencies of wild-type and mutant als strains, overview Lactococcus lactis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 pyruvate
-
 Lactococcus lactis 2-acetolactate + CO2
-
 ?
2 pyruvate
-
 Lactococcus lactis IL1403 2-acetolactate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
alpha-acetolactate synthase
-
 Lactococcus lactis

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Lactococcus lactis

General Information

General Information Comment Organism
malfunction the als defective strain, which is incapable of producing C4 compounds, appears sensitive to pyruvate under acidic conditions rendering it unable to grow. Accordingly, the als-mutant strain shows a simultaneous inability to alkalinize internal and external media Lactococcus lactis
metabolism strain IL1403 is able to cometabolize pyruvate and glucose at low pH, producing lactate, acetate as well as diacetyl/acetoin compounds. The enzyme is involved in the pyruvate metabolism in Lactococcus lactis, overview Lactococcus lactis
physiological function the enzyme contributes to pH homeostasis in acid stress conditions Lactococcus lactis