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Literature summary for 2.2.1.6 extracted from

  • Xing, R.; Whitman, W.B.
    Sulfometuron methyl-sensitive and -resistant acetolactate synthases of the archaebacteria Methanococcus spp. (1987), J. Bacteriol., 169, 4486-4492.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.6

Inhibitors

Inhibitors Comment Organism Structure
Ile no inhibition Methanococcus aeolicus
Ile
-
 Methanococcus maripaludis
Ile
-
 Methanococcus voltae
Leu no inhibition Methanococcus aeolicus
Leu
-
 Methanococcus maripaludis
Leu no inhibition Methanococcus voltae
Val feed-back inhibition Methanococcus aeolicus
Val feed-back inhibition Methanococcus maripaludis
Val feed-back inhibition Methanococcus voltae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 pyruvate
-
 Methanococcus voltae
2.3
-
 pyruvate
-
 Methanococcus aeolicus
4.2
-
 pyruvate
-
 Methanococcus maripaludis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ strong requirement Methanococcus aeolicus

Organism

Organism UniProt Comment Textmining
Methanococcus aeolicus
-
-
-
Methanococcus maripaludis
-
-
-
Methanococcus voltae
-
-
-
Methanothermococcus thermolithotrophicus
-
-
-

Oxidation Stability

Oxidation Stability Organism
10% O2, 37°C, 30 min, 90% loss of activity Methanococcus aeolicus
10% O2, 37°C, 30 min, 90% loss of activity Methanococcus maripaludis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate
-
 Methanothermococcus thermolithotrophicus 2-acetolactate + CO2
-
 ?
pyruvate
-
 Methanococcus aeolicus 2-acetolactate + CO2
-
 ?
pyruvate
-
 Methanococcus maripaludis 2-acetolactate + CO2
-
 ?
pyruvate
-
 Methanococcus voltae 2-acetolactate + CO2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Methanococcus aeolicus
thiamine diphosphate required as cofactor Methanothermococcus thermolithotrophicus
thiamine diphosphate required as cofactor Methanococcus aeolicus
thiamine diphosphate required as cofactor Methanococcus maripaludis
thiamine diphosphate required as cofactor Methanococcus voltae
thiamine diphosphate required after dialysis Methanococcus aeolicus
thiamine diphosphate required after dialysis Methanococcus maripaludis
thiamine diphosphate required after dialysis Methanococcus voltae
thiamine diphosphate Km: 0.0033 mM Methanococcus maripaludis
thiamine diphosphate Km: 0.0031 mM Methanococcus voltae