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Literature summary for 2.2.1.5 extracted from

  • Schlossberg, M.A.; Bloom, R.J.; Richert, D.A.; Westerfeld, W.W.
    Carboligase activity of alpha-ketoglutarate dehydrogenase (1970), Biochemistry, 9, 1148-1153.
    View publication on PubMed
Search for more literature for 2.2.1.5

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-
Rattus norvegicus
-
 rat
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain
-
 Bos taurus
-
heart
-
 Bos taurus
-
heart distribution in rat tissues Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Bos taurus
-
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-
muscle
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.8
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate decarboxylation Bos taurus ? + CO2
-
 ?
2-oxoglutarate + acetaldehyde
-
 Bos taurus 5-hydroxy-4-oxohexanoate + CO2
-
 ?
2-oxoglutarate + glyoxylate
-
 Rattus norvegicus 2-hydroxy-3-oxohexandioate + CO2
-
 ?
2-oxoglutarate + glyoxylate
-
 Bos taurus 2-hydroxy-3-oxohexandioate + CO2 also 2,3-dihydroxy-4-ketopimelic acid ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 enzyme assay at Rattus norvegicus
37
-
 enzyme assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 enzyme assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Rattus norvegicus
thiamine diphosphate
-
 Bos taurus