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Literature summary for 2.2.1.2 extracted from

  • Basta, P.V.; Bensen, J.T.; Tse, C.K.; Perou, C.M.; Sullivan, P.F.; Olshan, A.F.
    Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck (2008), Cancer Detect. Prev., 32, 200-208.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the results provide preliminary evidence that genetic polymorphisms in TALDO1 are associated with squamous cell carcinoma of the head and neck Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information sequencing analysis to identify common genetic variations in TALDO1 and their association with squamous cell carcinoma of the head and neck (SCCHN) using samples from a population-based case/control study with both European American and African American former and current smokers is performed. Three polymorphisms in TALDO1 are identified that are associated with SCCHN risk in our EA study population: specifically the 5’ upstream variant -490 C to G or T (SNP name: rs10794338), identified as tri-allelic, shows a reduced risk compared with any presence of the common allele. Two intronic high frequency polymorphisms demonstrate a positive association with disease, with the presence of the variant IVS1 + 1874 T to A (SNP name: rs3901233) and IVS4 + 2187A to C (SNP name: rs4963163) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
TALDO1
-
Homo sapiens
transaldolase 1
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Homo sapiens