Literature summary for 2.2.1.1 extracted from

Oh, S.H.; Witek, R.P.; Bae, S.H.; Darwiche, H.A.; Jung, Y.; Pi, L.; Brown, A.; Petersen, B.E.
Detection of transketolase in bone marrow-derived insulin producing cells: Benfotiamine enhances insulin synthesis and glucose metabolism (2009), Stem Cells Dev., 18, 37-46.

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Activating Compound

Activating Compound	Comment	Organism	Structure
benfotiamine	-	Rattus norvegicus
benfotiamine	not inhibitory on proliferation of insulinoma cell line INS-1. Treatment activates glucose metabolism in INS-1 cells in high-glucose culture conditions and maximizes the cells' ability to synthesize insulin. Treatment activates glucokinase	Rattus norvegicus

Application

Application	Comment	Organism
medicine	treatment of hyperglycemic mice with BM-derived IPCs transplantation and benfotiamine, whereby activation of transketolase by benfotiamine can be playing a significant role in upregulation of both glucose metabolism and insulin protein synthesis	Rattus norvegicus
pharmacology	benfotiamine treatment activates glucose metabolism in INS-1 cells in high-glucose culture conditions and maximizes the cells' ability to synthesize insulin. Treatment activates glucokinase	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
oxythiamine	inhibitory on proliferation of insulinoma cell line INS-1; when IPCs are cultured with oxythiamine, transketolase activity and insulin gene expression are suppressed	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow cell line	adult bone marrow-derived insulin-producing cells, presence of transketolase protein under high-glucose conditions	Rattus norvegicus	-
INS-1 cell	insulinoma cell line	Rattus norvegicus	-
INS-1 cell	insulinoma cell line. Proliferation of cells is not inhibited by transketolase inhibitor benfotiamine	Rattus norvegicus	-
additional information	BM-derived IPC cell, in bone marrow derived insulin-producing cells, transketolase is detectable under high glucose culture conditions	Rattus norvegicus	-

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Release 2023.1 (January 2023)