Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hydrogen peroxide | oxidative stress increases tktA expression. Induces tktA at 1 h treatment, while an increase in marRAB operon expression occurs only after 3 h exposure | Escherichia coli |
Application | Comment | Organism |
---|---|---|
medicine | TktA interacts with MarR. TktA decreases MarR repressor activity. Overexpressing tktA decreases antibiotic susceptibility. Endogenous TktA enhances multiple antibiotic resistance to a small degree through release of MarR repression of the marRAB operon | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
into vector pET21b, tktA overexpressed using the high-copy-number expression plasmid pSPOK in Escherichia coli SPC105 | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of tktA increases antibiotic and oxidative stress susceptibilities | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
on Ni-NTA resin-bound MarR | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
TktA | - |
Escherichia coli |
transketolase A | - |
Escherichia coli |