Application | Comment | Organism |
---|---|---|
medicine | transketolase may emerge as a target of multiple sclerosis cerebro-spinal fluid autoimmune response | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P29401 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | at the lesion border | Homo sapiens | - |
brain | in normal human brain transketolase is expressed on almost the totality of mature oligodendrocytes and scattered NG2-positive precursors, diffusely on ependymal cells and on distinct subsets of neuronal populations | Homo sapiens | - |
cerebral white matter | normal and multiple sclerosis samples | Homo sapiens | - |
macrophage | at the lesion border | Homo sapiens | - |
monocyte | at the lesion border | Homo sapiens | - |
additional information | diffuse expression of transketolase in ependymal cells of normal human brain. At the lesion border transketolase is expressed by oligodendrocyte precursors (NG2-positive precursor) | Homo sapiens | - |
oligodendrocyte | transketolase is mainly expressed by oligodendrocytes in normal conditions, but is also present in oligodendrocytes in normal appearing white matter around multiple sclerosis plaques | Homo sapiens | - |