Application | Comment | Organism |
---|---|---|
drug development | non-permanently charged thiamine mimetics (thiamine analogs possessing B-rings unable to participate in the cycle) are competent substrates for thiamine pyrophosphokinase, and the resulting pyrophosphates antagonize the activity of transketolase in vitro. Despite remarkable potencies in enzymatic assays, cellular potencies are modest to poor. Inhibition of the thiamine-utilizing enzyme transketolase is linked with diminished tumor cell proliferation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deazathiamine | retains thiamine pyrophosphokinase activity. Despite improvements in binding to transketolase in enzymatic assays, cell potency relative to the thiazolones and charged thiamine mimetics decrease | Homo sapiens | |
N3P-TT | an aminopyridine, which possesses low micromolar cellular potency against transketolase | Homo sapiens | |
thiamine thiazolone | retains thiamine pyrophosphokinase activity, is a significantly better binder to transketolase than thiamine | Homo sapiens | |
thiamine thiazolone diphosphate | is a significantly better binder to transketolase than thiamine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | thiamine B-ring is an essential component of catalysis | Homo sapiens |