BRENDA - Enzyme Database show
show all sequences of 2.1.4.2

The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: implications for evolution

Bedekar, A.; Zink, R.M.; Sherman, D.H.; Line, T.V.; Van Pilsum, J.F.; Comp. Biochem. Physiol. B 119B, 677-690 (1998)
No PubMed abstract available

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces galbus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces consensus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces glaucescens strB1
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces glaucescens strB2
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus strB2
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces bluensis
biosynthesis of streptomycin
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus
biosynthesis of streptomycin
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus SPH
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus ATCC 10137
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Streptomyces bluensis
Q53814
-
-
Streptomyces consensus
-
-
-
Streptomyces galbus
Q54256
genebank acc. No.
-
Streptomyces galbus
-
-
-
Streptomyces glaucescens strB1
Q54258
strB1, genebank acc. No.
-
Streptomyces glaucescens strB2
Q54264
strB2, genebank acc. No.
-
Streptomyces griseus
P08078
strB1, genbank seq.acc. number
-
Streptomyces griseus
-
; ATCC10137; strB2
-
Streptomyces griseus ATCC 10137
-
ATCC10137
-
Streptomyces griseus SPH
-
-
-
Streptomyces griseus strB2
P29780
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Streptomyces bluensis
-
mycelium
-
Streptomyces galbus
-
mycelium
-
Streptomyces griseus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces galbus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces consensus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces glaucescens strB1
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces glaucescens strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
biosynthesis of streptomycin
485976
Streptomyces bluensis
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
biosynthesis of streptomycin
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus SPH
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus ATCC 10137
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces galbus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces bluensis
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces consensus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces glaucescens strB1
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces glaucescens strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus SPH
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus ATCC 10137
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus
?
-
-
-
-
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus SPH
?
-
-
-
-
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus ATCC 10137
?
-
-
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces galbus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces consensus
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces glaucescens strB1
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces glaucescens strB2
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus strB2
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces bluensis
biosynthesis of streptomycin
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus
biosynthesis of streptomycin
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus SPH
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Streptomyces griseus ATCC 10137
-
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Streptomyces bluensis
-
mycelium
-
Streptomyces galbus
-
mycelium
-
Streptomyces griseus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces galbus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces consensus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces glaucescens strB1
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces glaucescens strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
biosynthesis of streptomycin
485976
Streptomyces bluensis
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
biosynthesis of streptomycin
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus SPH
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
485976
Streptomyces griseus ATCC 10137
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces galbus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces bluensis
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces consensus
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces glaucescens strB1
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces glaucescens strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus strB2
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus SPH
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
485976
Streptomyces griseus ATCC 10137
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
-
-
?
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus
?
-
-
-
-
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus SPH
?
-
-
-
-
additional information
enzyme cannot utilize glycine as guanidino acceptor
485976
Streptomyces griseus ATCC 10137
?
-
-
-
-
Other publictions for EC 2.1.4.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
485977
Fritsche
The ligand-induced structural ...
Streptomyces griseus
J. Biol. Chem.
274
3026-3032
1999
-
-
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485976
Bedekar
-
The comparative amino acid seq ...
Streptomyces bluensis, Streptomyces consensus, Streptomyces galbus, Streptomyces glaucescens strB1, Streptomyces glaucescens strB2, Streptomyces griseus, Streptomyces griseus ATCC 10137, Streptomyces griseus SPH, Streptomyces griseus strB2
Comp. Biochem. Physiol. B
119B
677-690
1998
-
-
-
-
-
-
-
-
-
-
-
11
-
11
-
-
-
-
-
3
-
-
25
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
11
-
-
-
-
-
3
-
-
25
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485989
Fritsche
Crystal Structure of L-Arginin ...
Streptomyces galbus, Streptomyces galbus strB1, Streptomyces glaucescens strB1, Streptomyces glaucescens strB2, Streptomyces griseus, Streptomyces griseus strB1
Biochemistry
37
17664-17672
1998
-
-
1
1
-
-
-
-
-
-
-
8
-
7
-
-
1
-
-
2
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
8
-
-
-
1
-
2
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485973
Humm
-
Recombinant expression and iso ...
Streptomyces griseus
Biochem. J.
322
771-776
1997
-
-
-
-
-
-
-
-
-
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-
1
-
1
-
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-
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-
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-
-
2
-
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-
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1
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-
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485971
Guthmiller
Cloning and sequencing of rat ...
Streptomyces griseus
J. Biol. Chem.
269
17556-17560
1994
-
-
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-
-
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-
1
-
1
-
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4
-
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1
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4
-
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-
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-
-
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-
-
-
-
485985
Tohyama
Nucleotide sequence of the str ...
Streptomyces bikiniensis, Streptomyces griseus
Nucleic acids Res.
15
1819-1833
1987
-
-
-
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-
1
2
-
4
-
-
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-
1
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5
-
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-
1
2
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485984
Walker
L-Arginine:inosamine-P amindin ...
Streptomyces bikiniensis, Streptomyces galbus, Streptomyces griseocarneus, Streptomyces humidus, Streptomyces hygroscopicus, Streptomyces ornatus
Methods Enzymol.
43
451-458
1975
-
-
-
-
-
-
10
-
-
-
-
6
-
6
-
-
2
-
-
6
1
-
26
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
6
-
-
-
2
-
6
1
-
26
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485983
Walker
Biosynthesis of the monoguanid ...
Streptomyces hygroscopicus
J. Biol. Chem.
249
2397-2404
1974
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485964
Walker
-
Amidinotranferases ...
Streptomyces bikiniensis, Streptomyces bluensis, Streptomyces galbus, Streptomyces griseocarneus, Streptomyces griseus, Streptomyces humidus, Streptomyces hygroscopicus
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
497-509
1973
-
-
-
-
-
-
-
-
-
-
-
7
-
7
-
-
1
-
-
5
-
-
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
1
-
5
-
-
23
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485981
Walker
Enzymic studies on the biosynt ...
no activity in Streptomyces griseus, no activity in Streptomyces griseus ATCC 10971, Streptomyces bikiniensis, Streptomyces bluensis, Streptomyces griseocarneus, Streptomyces griseus, Streptomyces griseus W4, Streptomyces kanamyceticus
J. Biol. Chem.
241
1262-1270
1966
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-
-
-
-
-
-
-
-
-
-
6
-
8
-
-
2
-
-
3
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
2
-
3
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-