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Literature summary for 2.1.4.1 extracted from
- The ligand-induced structural changes of human L-arginine:glycine amidinotransferase. A mutational and crystallographic study (1999), J. Biol. Chem., 274, 3026-3032.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ornithine | competitive inhibition | Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | 56000 | wild-type enzyme AT, mutant ATdelta11, mutant ATdeltaM302, gel filtration | Homo sapiens |
| 89200 | - |
mutant ATDELTA11, calculated molecular mass | Homo sapiens |
| 90000 | - |
mutant ATDELTAM302, sedimentation analysis | Homo sapiens |
| 90100 | - |
mutant ATDELTA11, sedimentation analysis | Homo sapiens |
| 91600 | - |
mutant ATDELTAM302, calculated molecular mass | Homo sapiens |
| 91800 | - |
wild-type enzyme AT, calculated molecular mass | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + glycine | Homo sapiens | - |
L-ornithine + guanidinoacetate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arginine + 3-aminopropionic acid | - |
Homo sapiens | 3-guanidinopropionic acid + ornithine | - |
? | |
| arginine + 4-aminobutyric acid | - |
Homo sapiens | 4-guanidinobutyric acid + ornithine | - |
? | |
| arginine + delta-aminovaleric acid | - |
Homo sapiens | delta-guanidinovaleric acid + ornithine | - |
? | |
| arginine + gamma-aminobutyric acid | - |
Homo sapiens | gamma-guanidinobutyric acid + ornithine | - |
? | |
| canavanine + glycine | - |
Homo sapiens | guanidinoacetate + canaline | - |
r | |
| canavanine + ornithine | - |
Homo sapiens | arginine + canaline | - |
r | |
| hydroxyguanidine + glycine | - |
Homo sapiens | hydroxylamine + guanidinoacetate | - |
? | |
| L-alanine + glycine | - |
Homo sapiens | ? | - |
? | |
| L-aminobutyric acid + glycine | - |
Homo sapiens | ? | - |
? | |
| L-arginine + glycine | - |
Homo sapiens | L-ornithine + guanidinoacetate | - |
r | |
| L-norvaline + glycine | - |
Homo sapiens | ? | - |
? | |
| additional information | homoarginine, alpha-amino-gamma-guanidinobutyric acid and alpha-amino-beta-guanidinopropionic acid are not substrates | Homo sapiens | ? | - |
? | |
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