Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thyroxine | induces enzyme expression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA, nucleotide sequence determined, cloned and expressed in Escherichia coli BL21(DE3)-pLysS | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
recombinant human enzyme, bipyramidal, tetragonal crystals, belonging to space group P4(3)2(1)2, lattice constants a = b = 83.6 A, c = 200.4 A and alpha = beta = gamma = 90° | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Creatine | represses enzyme expression | Homo sapiens | |
ornithine | - |
Homo sapiens | |
ornithine | - |
Rattus norvegicus | |
ornithine | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrial inner membrane | - |
Homo sapiens | 5743 | - |
mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
mitochondrial intermembrane space | - |
Homo sapiens | 5758 | - |
mitochondrion | - |
Sus scrofa | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + glycine | Homo sapiens | - |
L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | Rattus norvegicus | - |
L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | Sus scrofa | - |
L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | Homo sapiens | first reaction in the de novo biosynthesis of creatine | L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | Rattus norvegicus | first reaction in the de novo biosynthesis of creatine | L-ornithine + guanidinoacetate | - |
r | |
L-ornithine + guanidinoacetate | Sus scrofa | - |
L-arginine + glycine | - |
r | |
L-ornithine + guanidinoacetate | Homo sapiens | - |
L-arginine + glycine | - |
r | |
L-ornithine + guanidinoacetate | Rattus norvegicus | - |
L-arginine + glycine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Homo sapiens | P50440 | mitochondrial enzyme, DDBJ/EMBL/GenBank database, cDNA sequence | - |
Homo sapiens | P50440 | cytosolic enzyme, DDBJ/EMBL/GenBank database, cDNA sequence | - |
Rattus norvegicus | - |
rat | - |
Rattus norvegicus | P50442 | cDNA sequence, EMBL accession number | - |
Sus scrofa | - |
pig, porcine, hog | - |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
heart | - |
Homo sapiens | - |
muscle | - |
Sus scrofa | - |
muscle | - |
Homo sapiens | - |
muscle | - |
Rattus norvegicus | - |
neuron | - |
Homo sapiens | - |
photoreceptor | - |
Homo sapiens | - |
semen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
canavanine + ornithine | - |
Homo sapiens | arginine + canaline | - |
r | |
canavanine + ornithine | - |
Rattus norvegicus | arginine + canaline | - |
r | |
canavanine + ornithine | - |
Sus scrofa | arginine + canaline | - |
r | |
L-arginine + glycine | - |
Homo sapiens | L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | - |
Rattus norvegicus | L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | - |
Sus scrofa | L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | first reaction in the de novo biosynthesis of creatine | Homo sapiens | L-ornithine + guanidinoacetate | - |
r | |
L-arginine + glycine | first reaction in the de novo biosynthesis of creatine | Rattus norvegicus | L-ornithine + guanidinoacetate | - |
r | |
L-ornithine + guanidinoacetate | - |
Sus scrofa | L-arginine + glycine | - |
r | |
L-ornithine + guanidinoacetate | - |
Homo sapiens | L-arginine + glycine | - |
r | |
L-ornithine + guanidinoacetate | - |
Rattus norvegicus | L-arginine + glycine | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
dimer | - |
Rattus norvegicus |
dimer | - |
Sus scrofa |
monomer | - |
Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.253 | - |
ornithine | - |
Homo sapiens | |
0.253 | - |
ornithine | - |
Rattus norvegicus |