Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.4.1 extracted from

  • Sipilae, I.
    Inhibition of arginine-glycine amidinotransferase by ornithine. A possible mechanism for the muscular and chorioretinal atrophies in gyrate atrophy of the choroid and retina with hyperornithinemia (1980), Biochim. Biophys. Acta, 613, 79-84.
    View publication on PubMed

Application

Application Comment Organism
medicine presence of the enzyme in serum or urine may prove useful in development of kidney disease diagnosis, hyperornithinemia, an autosomal recessive disease caused by decreased enzyme activity, enzyme activity is also dimished in thyrotoxicosis and myotonic muscular dystrophy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ornithine competitive inhibition Homo sapiens
ornithine competitive inhibition Rattus norvegicus
ornithine
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.27
-
arginine
-
Sus scrofa
9.21
-
arginine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Gallus gallus 5739
-
mitochondrion
-
Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + glycine Gallus gallus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Homo sapiens
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Rattus norvegicus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Sus scrofa
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Rattus norvegicus Sprague-Dawley
-
L-ornithine + guanidinoacetate
-
r
L-ornithine + guanidinoacetate Gallus gallus
-
L-arginine + glycine
-
r
L-ornithine + guanidinoacetate Sus scrofa
-
L-arginine + glycine
-
r

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
chicken
-
Homo sapiens
-
human
-
Rattus norvegicus
-
-
-
Rattus norvegicus
-
rat
-
Rattus norvegicus Sprague-Dawley
-
-
-
Sus scrofa
-
pig, porcine, hog
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
fibroblast
-
Homo sapiens
-
kidney
-
Gallus gallus
-
kidney
-
Sus scrofa
-
liver
-
Gallus gallus
-
liver
-
Sus scrofa
-
lymphocyte
-
Homo sapiens
-
muscle
-
Sus scrofa
-
pancreas
-
Gallus gallus
-
pancreas
-
Sus scrofa
-

Storage Stability

Storage Stability Organism
-18°C, homogenized tissues stored during 1 month without any loss of enzyme activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
canavanine + ornithine
-
Gallus gallus arginine + canaline
-
r
canavanine + ornithine
-
Homo sapiens arginine + canaline
-
r
canavanine + ornithine
-
Rattus norvegicus arginine + canaline
-
r
canavanine + ornithine
-
Sus scrofa arginine + canaline
-
r
canavanine + ornithine
-
Rattus norvegicus Sprague-Dawley arginine + canaline
-
r
L-arginine + glycine
-
Gallus gallus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Homo sapiens L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Rattus norvegicus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Sus scrofa L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Rattus norvegicus Sprague-Dawley L-ornithine + guanidinoacetate
-
r
L-ornithine + guanidinoacetate
-
Gallus gallus L-arginine + glycine
-
r
L-ornithine + guanidinoacetate
-
Sus scrofa L-arginine + glycine
-
r